EPIDEMIOLOGIA MOLECULAR DE MRSA NO BRASIL

Jacksiane Brandão Silva, Maria Luísa Candido Ribeiro, Caroline Mota Souza Barboza

Resumo


O Staphylococcus aureus resistente à meticilina (MRSA), tem sido uma grande preocupação para a saúde pública. Entretanto, estudos recentes vêm demonstrando avanços na disseminação de cepas em ambientes comunitários. Historicamente, as linhagens de complexo clonal 30 (CC30) e 5 (CC5) só eram associados a ambientes comunitários (CA-), mas ultimamente vêm sendo associados a ambientes hospitalares (HA-). O clone epidêmico Brasileiro (BEC), um HA-MRSA de SCCmec tipo IIIA, era descrito como a linhagem mais disseminada no Brasil, porém, estudos recentes têm apresentado uma mudança epidemiológica, e os complexos clonais mais observados têm sido o CC5 e do CC30, de SCCmec tipo IV ou V. Este trabalho tem como objetivo avaliar a epidemiologia molecular de MRSA no Brasil, baseado na literatura mais recente.

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Referências


ADHIKARI, Rajan P., et al. Phenotypic and molecular characterization of community occurring, Western Samoan phage pattern methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, v. 50, n. 6, p. 825-831, 2002. Disponível em: < https://academic.oup.com/jac/article/50/6/825/809922 >. Acesso em: 23/08/0219.

AMMERLAAN, H. S. M. e BONTEN, M. J. M., Daptomycin: Graduation Day, CMI, v.12, suppl. 8, p. 22- 28, Dec.2006. Disponível em: < https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2006.01627.x >. Acesso em: 18/09/2019.

ANTHONISEN, I.L. et al. Organization of the Antiseptic Resistance Gene qacA and Tn552-Related-Lactamase Genes in Multidrug-Resistant Staphylococcus haemolyticus Strains of Animal and Human Origins. American Society for Microbiology. Antimicrobial Agents and Chemotherapy. Vol.46, No.11, p.3606–3612, 2002. Disponível em: . Acesso em: 12/08/2019.

APPELBAUM, P. C., Microbiology of Antibiotic Resistance in Staphylococcus aureus. Oxford Academic – Infectious Diseases Society of America (IDSA). Vol. 45 (suppl. 3), pages S165 – S170, 2007. Disponível em: < https://doi.org/10.1086/519474>. Acesso em : 23/08/2019.

BANNERMAN, T. L.; HANCOCK, G. A. et al. Pulsed-Field Gel Eletrophoresis as a Replacement for Bacteriophage Typing of Staphylococcus aureus. JOURNAL OF CLINICAL MICROBIOLOGY. Vol. 33, p. 551–555, 1995. Disponível em: . Acesso em:23/08/2019.

CAVALCANTE, F. S. et al. High Prevalence of Methicillin Resistance and PVL Genes Among Staphylococcus aureus isolates from the nares and skin lesions of pediatric patients with atopic dermatitis. Brazilian Journal of Medical and Biological Research. Vol. 48, n. 7, p. 588-594, 2015. Disponível em: Acesso em:18/09/2019.

CHAMBERS HF. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. American Society for Microbiology. Clinical Microbiology Reviews. Vol.10, p. 781-791, 1997. Disponível em: . Acesso em: 18/09/2019.

DERESINSKI, S., Methicillin-Resistant Staphylococcus aureus: an Evolutionary, Epidemiologic, and Therapeutic Odyssey. Oxford Academic – Infectious Diseases Society of America (IDSA). Clin. Infect. Dis; n. 40, p 562-573, 2005. Disponível em: < https://doi.org/10.1086/427701>. Acesso em: 14/08/2019.

DEURENBERG, Ruud H.; STOBBERINGH, Ellen E. The molecular evolution of hospital-and community-associated methicillin-resistant Staphylococcus aureus. Current molecular medicine, v. 9, n. 2, p. 100-115, 2009. Disponível em: Acesso 14/08/2019.

DINGES, M. M., ORWIN, P. M., SCHLIEVERT, P. M., Exotoxins of Staphylococcus aureus. American Society Microbiology. Clinical Microbiology Reviews. Vol. 13, n. 1, p. 16-34, 2000. Disponível em: . Acesso em:23/10/2019.

ENRIGHT, M. C., DAY, N. P. J., DAVIES, C. E., et al, Multilocus Sequence Typing for Characterization of Methicillin-resistant and Methicillin-Susceptible Clones of Staphylococcus aureus. J. Clin. Microbiol, v. 38, n. 3, p 1008 – 1015, 2000. Disponível em: . Acesso em:14/08/2029.

FENG Y, Chen CJ,Su LH, Hu S, Yu J, Chiu CH. Evolution and pathogenesis of Staphylococcus aureus: lessons Iearned from genotyping and comparative genomics. FEMS Microbiol Ver. 32(1):23-37, 2008. Disponível em: .

FRENAY, HME et al. Tipagem molecular de Staphylococcus aureus resistente à meticilina com base no polimorfismo do gene da proteína A. European Journal of Clinical Microbiology and Infectious Dissecasses, v. 15, n. 1, p. 60-64, 1996. Disponível em: Acesso em: 23/10/2019.

GOOTZ, Thomas D. The forgotten Gram-negative bacilli: what genetic determinants are telling us about the spread of antibiotic resistance. Biochemical pharmacology, v. 71, n. 7, p. 1073-1084, 2006. Disponível em: . Acesso em: 14/08/2019.

ITO T, Ma XX, Takeuchi F, Okuma K, Yuzawa H, Hiramatsu K. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob Agents Chemother 48: 2637-2651, 2004. Disponível em: . Acesso em:20/07/2019.

JEVONS, M. Patricia. “Celbenin”-resistant staphylococci. British medical journal, v. 1, n. 5219, p. 124, 1961. Acesso em: 23/09/2019.

JEVONS, Colin. Universities: a prime example of branding going wrong. Journal of Product & Brand Management, v. 15, n. 7, p. 466-467, 2006. Disponível em: .

KAPLAN, Sheldon L. Treatment of community-associated methicillin-resistant Staphylococcus aureus infections. The Pediatric infectious disease journal, v. 24, n. 5, p. 457-458, 2005. Acesso em: 06/09/2019.

KARCHMER, A. W., From Theory to Practice: Resistance in Sthaphylococcus aureus and New Treatments, Clin Microbiol Infect, v.12, suppl.8, p. 15- 21, Dec. 2006. Disponível em: .

KLEVENS, R. Monina et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. Jama, v. 298, n. 15, p. 1763-1771, 2007. Disponível em: . Acesso em: 08/06/2019

KLUYTMANS, J. A. J. W.; WERTHEIM, H. F. L. Nasal carriage of Staphylococcus aureus and prevention of nosocomial infections. Infection, v. 33, n. 1, p. 3-8, 2005. Disponível em: .

LOWY, Franklin D. Antimicrobial resistance: the example of Staphylococcus aureus. The Journal of clinical investigation, v. 111, n. 9, p. 1265-1273, 2003. Disponível em: .

MATOUSKOVA, Ivanka et al. Current knowledge of methicillin-resistant Staphylococcus aureus and community-associated methicillin-resistant Staphylococcus aureus. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, v. 152, n. 2, p. 191-202, 2008. Disponível em: . Acesso em:21/06/2019.

MURRAY, P. R., Microbiologia Médica, Ed. 3, Rio de Janeiro: Guanabara Koogan, 1992.

NETO, André Domingos Egidio. Perfil genotípico de amostras de Staphylococcus aures resistente a meticilina em crianças e adolescentes no município de Niterói, Rio de Janeiro. 2016. Disponível em: . Acesso em:05/07/2019.

OLIVEIRA D.C., De Lencastre H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 46:2155-61, 2002. Disponível em: . Acesso em: 14/08/2019.

OLIVEIRA, Geraldo A. et al. Characterization of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil. Brazilian Journal of Infectious Diseases, v. 5, n. 4, p. 163-170, 2001.

PALAVECINO, E. Clinical, Epidemiological, and laboratory Aspects of Methicilin-Resistant Staphylococcus aureus (MRSA) Infections. Methods in molec biol 391: 1-19. 2007. Disponível em: . Acesso em: 23/07/2019.

PEREIRA, Valéria Cataneli et al. Caracterização do perfil clonal de MRSA isolado em unidades de terapia intensiva neonatal e pediátrica de um hospital universitário. Anais de microbiologia clínica e antimicrobianos, v. 13, n. 1, p. 50, 2014. Acesso em: 21/06/2019.

PEREZ, Leandro Reus Rodrigues; D'AZEVEDO, Pedro Alves. Clonal types and antimicrobial resistance profiles of methicillin-resistant Staphylococcus aureus isolates from hospitals in south Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 50, n. 3, p. 135-137, 2008. Disponível em: .

REINERT, Cristina et al. Type IV SCCmec found in decade old Brazilian MRSA isolates. Brazilian Jornal Infectous Diseases, Salvador. Vol. 12, n. 3, p. 213-216, June 2008. Disponível em: .

RIBAS, Rosineide Marques et al. Conventional versus molecular tests (Multiplex PCR and PCR mecA gene) for detection of methicillin resistant Staphylococcus aureus. Brazilian. Journal of Microbiology, v. 34, p. 35-37, 2003. Disponível em: < http://dx.doi.org/10.1590/S1517-83822003000500012>.

RIBEIRO A, Dias C, Silva-Carvalho C et al. First report of infectin with community-acquired methicillin-resistant Staphylococcus aureus in South America. J Clin Microbiol 2005. Disponível em: . Acesso em:14/09/2019.

RODRIGUEZ-NORIEGA, Eduardo; SEAS, Carlos. The changing pattern of methicillin-resistant Staphylococcus aureus clones in Latin America: implications for clinical practice in the region. Brazilian Journal of Infectious Diseases, v. 14, p. 87-96, 2010. Disponível em: .

RYFFEL, C., et al. Sequence comparison of mecA genes isolated from methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. Gene 94: 137-138, 1990. Disponível em: .

SAKAI, H. PROCOP, G. W., KOBAYASHI, N., et al. Simultaneous detection of Staphylococcus aureus and coagulase-negative staphylococci in positive blood cultures by real-time PCR with two fluorescence resonance energy transfer probe sets. Journal of Clinical Microbiology, v. 42, n. 12, p. 5739 – 5744, 2004. Disponível em: . Acesso em:13/07/2019.

SALES, Laís Monteiro; DA SILVA, Tatiane Mendes. Staphylococcus aureus Meticilna Resistente: Um Desafio para a Saúde Pública. Acta Biomedica Brasiliensia, v. 3, n. 1, p. 1-13, 2012. Disponível em: . Acesso em:18/06/2019.

SILVA, Leticia Vale Scribel da. Epidemiologia clínica de Staphylococcus aureus resistentes a meticilina carreadores de cassete cromossomico estafilocócio mec tipo IV de pacientes atendidos em hospital universitário de Porto Alegre. 2009. 67 f. Tese (Doutorado) - Curso de Ciências Medicas, Universidade Rio Grande do Sul, Rio Grande do Sul, 2009. Disponível em: . Acesso em: 03/09/2019.

SOUSA-JUNIOR, F.C. de et al. Genotyping of methicillin-resistant Staphylococcus aureus isolates obtained in the Northeast region of Brazil. Brazilian Jornal of Medical and Biological Research. Ribeirão Preto, v. 42, n. 10, p. 877-881, Oct. 2009. Disponível em: .

SOUZA, M.A.; Miragaia M.; Sanches H.S., et al. Three-year assessment of methicillin-resistant Staphylococcus aureus clones in Latin America from 1996 to 1998. Brazilian Jornal of Infectious Diseases, 2001. 39:2 197-205. Disponível em: .

SPICER, W. J., Bacteriologia, Micologia e Parasitologia Clínica. Ed. 1, Rio de Janeiro: Guanabara Koogan, 2002.

STEFANI, Stefania et al. Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods. International journal of antimicrobial agents, v. 39, n. 4, p. 273-282, 2012. Disponível em: .

STEPHENS, Craig et al. Draft genome sequence of a community-associated methicillin-resistant Panton-Valentine leukocidin-positive Staphylococcus aureus sequence type 30 isolate from a pediatric patient with a lung infection in Brazil. Genome Announc., v. 3, n. 4, p. e00907-15, 2015. Disponível em: . Acesso em: 12/10/2019.

TENOVER, F. C., ARBEIT, R. D., GOERING, R. V., et al. How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: a review for healthcare epidemiologists. Molecular Typing Working Group of the Society for Healthcare Epidemiology of America. Infect Control Hosp Epidemiol, v.18, n.6, p.426 – 439, 1997. Disponível em: . Acesso em:03/08/2019.

TIETZ, Andreas; FREI, Reno; WIDMER, Andreas F. Transatlantic spread of the USA300 clone of MRSA. New England Journal of Medicine, v. 353, n. 5, p. 532-533, 2005. Disponível em: . Acesso em:12/10/2019.

UDO, E. E.; PEARMAN, J. W.; GRUBB, W. B. Genetic analysis of community isolates of methicillin-resistant Staphylococcus aureus in Western Australia. Journal of Hospital Infection, v. 25, n. 2, p. 97-108, 1993. Disponível em: .

VAN BELKUM, Alex et al. Reclassification of Staphylococcus aureus nasal carriage types. The Journal of infectious diseases, v. 199, n. 12, p. 1820-1826, 2009. Disponível em: .

VIEIRA, Maria Teresa C. et al. Living conditions as a driving factor in persistent methicillin-resistant Staphylococcus aureus colonization among HIV-infected youth. The Pediatric infectious disease journal, v. 35, n. 10, p. 1126-1131, 2016. Disponível em: . Acesso em: 18/07/2019.

WHITENER, C., CAPUTO, G. M., WEITEKAMP, M. R., et al. Endocarditis due to coagulase-negative staphylococci: microbiologic, epidemiologic and clinical considerations. Infectious Disease Clinics of North America, v. 7, n. 1, p. 81 – 96, 1993. Disponível em: . Acesso em:15/08/2019.

WIELDERS, A.L.C. et al. MecA Gene Is Widely Disseminated in Staphylococcus aureus Population. Journal of Clinical Microbiology, v.40, n.11, p.3970-3975, 2002. Disponível em: . Acesso em:12/10/2019.

ZETOLA, N., FRANCIS, J. S., NUERMBERG, E. L., et al., Community-acquired methicillin-resistant Staphylococcus aureus: na emerging threat. Lancet Infect Dis; 5: 275 - 286, 2005. Disponível em: . Acesso em: 26/07/2019.


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